France captain Pascal Pape could miss next weekend's home RBS 6 Nations match against holders Wales after picking up a back injury during the 23-18 loss in Italy on Sunday, the French federation (FFR) said.
Lock Papé had to leave the pitch after suffering a blow in a rough challenge midway through the second half.
"Examination showed he had been suffering a back injury. He is doubtful for next Saturday's match against Wales at the Stade de France," FFR said in a statement.
Both sides need a victory to maintain their title hopes after Wales lost 30-22 at home to Ireland on Saturday.