England flanker Tom Johnson has been ruled out of the RBS 6 Nations championship with a knee ligament injury.
Head coach Stuart Lancaster announced at today's tournament launch that Johnson is facing three months on the sidelines.
Loosehead prop Alex Corbisiero will miss England's first two fixtures, against Scotland and Ireland, after today undergoing a procedure to clean out his troublesome knee.
And England will also be without Freddie Burns for at least the Scotland game on 2 February, with the Gloucester fly-half expected to be out for two to three weeks with knee ligament damage.
Lancaster added that it was "too early to tell" whether Manu Tuilagi will have recovered from an ankle injury in time for the tournament opener at Twickenham.
In more positive injury news for England, full-back Alex Goode has overcome a shoulder problem and will play for Saracens against Cardiff Blues in the LV= Cup this weekend.