Delon Armitage will start on the left wing for England in place of Mark Cueto in Saturday's decisive Rugby World Cup Pool B showdown with Scotland.
Armitage features as one of three changes from last weekend's 67-3 victory over Romania, which was sparked by a quick-fire hat-trick from Cueto on his comeback from injury.
Matt Stevens starts at loosehead prop following an ankle injury and Courtney Lawes returns to the second row, having served a two-match ban.
An England victory will seal their passage to the World Cup quarter-finals as group winners - but defeat without any bonus points could bring their campaign to a crashing halt.
Alex Corbisiero and Tom Palmer drop to the bench but there is no place in the 22 for Cueto, with the more versatile Matt Banahan preferred among the replacements.
Number eight Nick Easter has replaced Tom Wood among the replacements after recovering from the back injury that kept him sidelined from the victories over Georgia and Romania.
Chris Ashton, whose five tries so far make him the tournament's leading try-scorer, Ben Foden, Manu Tuilagi, Dan Cole and James Haskell will all have started every England pool game.
Captain Lewis Moody will win his 70th cap on Saturday and Jonny Wilkinson his 90th.
England team: B Foden (Northampton Saints); C Ashton (Northampton Saints), M Tuilagi (Leicester Tigers), M Tindall (Gloucester Rugby), D Armitage (London Irish); J Wilkinson (Toulon), B Youngs (Leicester Tigers); M Stevens (Saracens), S Thompson (London Wasps), D Cole (Leicester Tigers), L Deacon (Leicester Tigers), C Lawes (Northampton Saints), T Croft (Leicester Tigers), L Moody (Bath Rugby, capt), J Haskell (Ricoh Black Rams).
Replacements: D Hartley (Northampton Saints), A Corbisiero (London Irish), T Palmer (Stade Francais), N Easter (Harlequins), R Wigglesworth (Saracens), T Flood (Leicester Tigers), M Banahan (Bath Rugby).