Robbie Henshaw, who last week earned his first Ireland U-20 cap, returns at full back for Connacht for the home RaboDirect Pro 12 tie against the Ospreys on Friday.
Tiernan O'Halloran, who covered the full back position last week, now returns to the right wing.
Kyle Tonetti retain the number 12 shirt and joins up with Eoin Griffin again in the centre.
Meanwhile, the front five in the pack remains unchanged with Nathan While captaining the side at The Sportsground.
Recent returnees John Muldoon and Willie Faloon were brought off the bench against Scarlets last Friday. This week, they both start in the back row, replacing Andrew Browne and Johnny O'Connor respectively.
Gavin Duffy is named on the bench and could make his 150th Connacht appearance.
Connacht XV to play Ospreys:
Robbie Henshaw, Tiernan O'Halloran, Eoin Griffin, Kyle Tonetti, Danie Poolman, Dan Parks, Kieran Marmion,
Brett Wilkinson, Jason Harris-Wright, Nathan White (capt), Michael Swift, Mick Kearney, John Muldoon, Willie Faloon, Eoin McKeon