Stuart Olding will make his first start for Ulster at a sold out Ravenhill on Friday night against Ospreys, kick-off 7.05pm.
The 19-year-old Ireland Under-20 out-half has made three previous appearances, all as a replacement for the RaboDirect PRO12 leaders.
Johann Muller has returned from injury to captain the side, as has Luke Marshall, who will line out in the unfamiliar outside centre position.
Ballymena prop Andrew Warwick is in line to make his senior debut for the Province after being named on the bench.
Callum Black will start at loose-head prop so Tom Court moves to the other side of the scrum with Rob Herring as hooker.
Lewis Stevenson retains his place in the second row beside Muller, despite the return to action of Dan Tuohy who is among the replacements. Mike McComish and Ali Birch get opportunities in the back row alongside the dynamic Robbie Diack.
Olding will be surrounded by experience in the form of Ruan Pienaar (scrumhalf) and Paddy Wallace (inside centre). Outside Marshall at 13 will be Andrew Trimble and Michael Allen on the wings, with Ricky Andrew at fullback.
The bench features 21-year-old Warwick and Belfast Harlequins duo Niall Annett and Ricky Lutton as the front row cover. Tuohy and Neil McComb will offer plenty of options, particularly in the line out, if they are called upon, while Paul Marshall, Darren Cave and Chris Cochrane are the backline subs.