Denis Hurley makes his return to action on Saturday for the RaboDirect Pro12 tie away to the Ospreys.
The player has recovered from tonsillitis which kept him sidelined for the Dragons game last weekend.
Conor Murray makes his first start of the season after coming off the bench for Ulster and Dragons, while Donnacha Ryan and Peter O’Mahony are included for the first time in a match day squad this season.
Munster v Ospreys in RaboDirect Pro12 on Saturday, 29 September, kick-off 6.30pm:
D Hurley; D Howlett Capt., K Earls, C Laulala, S Zebo, R O’Gara, C Murray; W Du Preez, M Sherry, S Archer, D O’Callaghan, B Holland, T O’Donnell, N Ronan, P Butler.
Replacements: D Varley, D Kilcoyne, BJ Botha, D Ryan, P O’Mahony, P Stringer, I Keatley, J Downey.