Ireland coach Les Kiss has named a highly-experimental team for Sunday morning’s clash with the US Eagles in Houston.
There are two new caps, with Connacht’s Robbie Henshaw named at full-back and Ulster’s Stuart Olding included at centre.
Three other players - Ian Madigan, David Kilcoyne and Iain Henderson - will start for Ireland for the first time, having previously been capped off the bench.
There are a further three uncapped players in the replacements, with Mike Sherry, Jamie Hagan and Tommy O’Donnell all included.
Mike Ross is the most capped player in the side and he packs down with Richardt Strauss and Kilcoyne.
Mike McCarthy and Devin Toner form the second row pairing, with Henderson and Chris Henry on either side of new Ireland captain Peter O’Mahony in the back row.
Speaking ahead of the game, Kiss said: “We’ve had a good week of preparation and the players have settled well in Houston.
“This is a young team with five players starting for the first time and we are under no illusions as to the challenge posed by an experienced and improving USA Eagles team.”
Ireland: R Henshaw, F McFadden, D Cave, S Olding, S Zebo, I Madigan, I Boss, D Kilcoyne, R Strauss, M Ross, M McCarthy, D Toner, I Henderson, C Henry, P O’Mahony.
Replacements: M Sherry, J Hagan, T Court, D Tuohy, T O’Donnell, P Marshall, P Jackson, F Jones.