Wales centre Jonathan Davies has been ruled out of the remaining autumn Tests due to a chest injury and could miss next year's Six Nations, as Warren Gatland calls up four players to the squad.
British & Irish Lion Davies sustained the injury trying to stop South Africa's Jean de Villiers scoring his team's first try in Saturday's 24-15 win over Wales in Cardiff.
"If he needs an operation it could be five months," Wales coach Warren Gatland told the BBC.
"He's pretty disappointed. The physio said it might settle and he could be back in December. We will wait and see what happens."
Gatland was already without Jamie Roberts, who usually partners Davies in the centre, and winger Alex Cuthbert for the autumn Tests while prop Adam Jones suffered a calf injury during the game against South Africa.
Further information on the extent of their injuries is expected on Monday.
FOUR PLAYERS ADDED TO WALES SQUAD
In the wake of the South Africa defeat Gatland has also called up four players to the squad.
Scarlets props Samson Lee and Rhodri Jones, plus Newport Gwent Dragons backs Hallam Amos and Tom Prydie will provide cover after the Six Nations champions lost a quartet of players to injury by half-time of Saturday's 24-15 Millennium Stadium defeat.
A statement from the Welsh Rugby Union read: "Scarlets props Samson Lee and Rhodri Jones and Newport Gwent Dragons duo Hallam Amos and Tom Prydie will train with the Wales squad this week."
Wales Under-20s cap Lee has worked with the national squad before as has his regional colleague Rhodri Jones, who has two caps to his name.
Amos is uncapped but has made a good start to the season with the Dragons, while Prydie, Wales' youngest international having made his debut aged 18 years and 25 days in 2010, featured on the summer tour of Japan.
Ospreys wing Eli Walker, who missed out on a Test debut against the Springboks due to a hamstring problem, and Cardiff Blues fly-half Rhys Patchell (shoulder) have returned to their regions for further treatment.