Ospreys wing Eli Walker will make his Wales debut in Saturday's Millennium Stadium clash against South Africa.
The 21-year-old fills the vacancy created by Alex Cuthbert, who is nursing an ankle injury, while centre Scott Williams partners his Scarlets colleague Jonathan Davies in midfield.
There is also a return for fly-half Rhys Priestland after he missed last season's entire title-winning RBS 6 Nations campaign due to an Achilles tendon injury.
And Cardiff Blues lock Bradley Davies has won coach Warren Gatland's vote to form the second-row pairing with Alun-Wyn Jones in a team captained by flanker Sam Warburton.
Wales team to play South Africa: L Halfpenny; G North, J Davies, S Williams, E Walker; R Priestland, M Phillips; G Jenkins, R Hibbard, A Jones, B Davies, A-W Jones, D Lydiate, S Warburton (capt), T Faletau.
Replacements: K Owens, P James, S Andrews, L Charteris, J Tipuric, Lloyd Williams, J Hook, Liam Williams.