Leicester hooker Tom Youngs will make his Test debut against Fiji on Saturday after being confirmed in one of the most inexperienced England sides of the professional era.
Youngs will take over the hooking duties from Dylan Hartley, who has been sidelined with a knee injury which threatens to keep him out of England's entire QBE autumn international series.
Ugo Monye will make his England comeback on the left wing in place of the injured Ben Foden, while Charlie Sharples deputise for the suspended Chris Ashton on the right wing.
Alex Goode continues at full-back while Brad Barritt and Manu Tuilagi link up in a hard-hitting centre partnership, with Toby Flood and Danny Care the half-backs.
There are a total of five changes from the 14-14 draw with South Africa in the summer, with Chris Robshaw back to captain the side after missing that Test with a broken hand.
Tom Johnson continues at blindside flanker after making his Test debut on the summer tour, while Tom Wood returns to the England fold after 14 injury-plagued months with a place on the bench.
England team to play Fiji in QBE international on Saturday at Twickenham, kick-off 2.30pm:
A Goode; C Sharples, M Tuilagi, B Barritt, U Monye; T Flood, D Care; J Marler, T Youngs, T Palmer, G Parling, T Johnson, C Robshaw (capt), T Waldrom.
Replacements: D Paice, D Wilson, M Vunipola, J Launchbury, T Wood, B Youngs, O Farrell, M Brown.