Uncapped forwards Mako Vunipola and Tom Youngs have been called into the England squad for the QBE autumn internationals.
England coach Stuart Lancaster has made four injury-enforced changes to the elite squad he originally named in July for the Tests against Fiji, Australia, South Africa and New Zealand.
Saracens prop Vunipola, whose father played at two World Cups for Tonga, and Leicester hooker Young are covering for Alex Corbisiero and Rob Webber.
Harlequins wing Ugo Monye has also been promoted to fill the back three berth left vacant when Ben Foden damaged ankle ligaments playing for Northampton.
James Haskell, who returned to the England team for the drawn third Test against South Africa in Port Elizabeth on the summer tour, has been promoted from the Saxons to replace Tom Croft.
England's elite squad for the QBE autumn internationals:
Backs: A Allen (Leicester), C Ashton (Saracens), B Barritt (Saracens), M Brown (Harlequins), D Care (Harlequins), L Dickson (Northampton), O Farrell (Saracens), T Flood (Leicester), A Goode (Saracens), J Joseph (London Irish), U Monye (Harlequins), C Sharples (Gloucester), M Tuilagi (Leicester), J Turner-Hall (Harlequins), B Youngs (Leicester).
Forwards: M Botha (Saracens), D Cole (Leicester), P Dowson (Northampton), D Hartley (Northampton), J Haskell (Wasps), T Johnson (Exeter), C Lawes (Northampton), J Marler (Harlequins), B Morgan (Gloucester), T Palmer (Wasps), G Parling (Leicester), C Robshaw (Harlequins), M Vunipola (Saracens), T Waldrom (Leicester), D Wilson (Bath), T Wood (Northampton), T Youngs (Leicester).