Munster captain Peter O’Mahony has been left of the squad for their opening Heineken Cup tie with Edinburgh on Saturday.
The flanker suffered a heavy collision with the knee of Sean Cronin during last week’s PRO12 win over Leinster.
He was replaced at half-time and Munster have decided, due to a busy schedule of games in the coming weeks, not to risk the 24-year-old.
Paul O’Connell will captain the side when they run out in Murrayfield at 1.35pm.
With O’Mahony ruled out, there is one change to the pack that defeated Leinster last weekend with Paddy Butler coming into the squad and making his first Heineken Cup start, as he joins Niall Ronan and James Coughlan in the back-row.
There is one change to the back-line also with Conor Murray moving into the starting XV and Duncan Williams named in the replacements.
Meanwhile, Edinburgh will be without centre Ben Atiga for at least a month after he dislocated a finger against Cardiff last weekend.
Munster: Felix Jones, Keith Earls, Casey Laulala, James Downey, Simon Zebo, Ian Keatley, Conor Murray, Dave Kilcoyne, Mike Sherry, Stephen Archer, Donncha Ryan, Paul O’Connell (c), Paddy Butler, Niall Ronan, James Coughlan.
Replacements: Damien Varley, James Cronin, BJ Botha, Donncha O’Callaghan, CJ Stander, Duncan Williams, JJ Hanrahan, Denis Hurley.
Live radio coverage of Ospreys v Leinster on Saturday Sport from 14:45 on Saturday 12 October on RTÉ Radio 1 and RTÉ.ie (Worldwide).