Castres out-half Remi Tales has pulled out of France's Six Nations opener against England after failing to recover from an arm injury and has been replaced by Francois Trinh-Duc, the French federation said.
Full-back Jean-Marcellin Buttin will leave the squad after picking up an injury in a Top 14 game with his Clermont team on Saturday and will be replaced by Marc Andreu, the FFR added.
"Francois Trinh-Duc is back with us. Remi will heal and we hope he will be back on the turf very soon," France manager Philippe Saint-Andre said in a statement.
Montpellier's Trinh-Duc won his last cap in a Six Nations game against Scotland last year.