Toast Of New York has been drawn in stall one for the Belmont Invitational Derby on Saturday evening.
Jamie Osborne's pride and joy already has one Derby to his name, when victorious in the UAE version at Meydan in March.
Connections now get the chance to see if their decision to skip the Epsom Classic was worthwhile.
"Toast Of New York has been working really well, he is going into the race in the form of his life and we're hopeful and looking forward to a big run," said Osborne.
The horse's owner, Michael Buckley, is more used to being represented at the Cheltenham Festival but is planning more overseas raids if all goes to plan.
"It's thrilling to own a lovely colt such as Toast Of New York, and it is a happy coincidence that after I named him after the Cary Grant movie, he is good enough to contest a race in the State which gave him his name," he said.
"If we are lucky enough to win the Belmont Derby, we might consider going for the Pacific Classic at Del Mar towards the end of August. The ultimate goal, if we think we could be competitive, would be the Dubai World Cup next year.
Among those taking on Toast Of New York are Aidan O'Brien's Adelaide, second in the King Edward VII at Royal Ascot, and Bobby's Kitten, third behind Outstrip at the Breeders' Cup Juvenile Turf in November.
Australian training legend Gai Waterhouse also has her first runner in the States in the shape of Pornichet, formerly trained in France.