Sprinter Sacre features among 26 entries for the BetVictor Queen Mother Champion Chase at the Cheltenham Festival on 12 March.
Nicky Henderson's superstar has questions to answer after being diagnosed with a fibrillating heart on his first start of the season when pulled up at Kempton.
While his participation is still in the balance, last year's winner remains the standout contender.
Henderson has also entered Captain Conan, Kid Cassidy and French Opera.
Paul Nicholls has given King George third Al Ferof the option and has also entered his top-class novices Dodging Bullets and Hinterland.
Sire De Grugy took advantage of Sprinter Sacre's ailments at Christmas and is a possible for Gary Moore, while former winner Sizing Europe could have another crack for Henry de Bromhead, who has also entered Special Tiara.
Last year's Arkle runner-up Baily Green, Tony Martin's Benefficient, Willie Mullins' pair of Arvika Ligeonniere and Twinlight and John Hanlon's Hidden Cyclone are all also engaged.
One notable omission is Colin Tizzard's Betfair Chase winner Cue Card, but he has been entered in the Ryanair Chase.
De Bromhead has also entered the veteran Sizing Europe in the Ryanair and he will now head straight to the Festival after disappointing at Leopardstown over Christmas.