The Fugue went one place better in the Darley Yorkshire Oaks with an authoritative victory at York.
Second to Shareta 12 months ago, William Buick's mount went off the 2-1 favourite, despite a disappointing showing last time in the Eclipse, when she was found to be have been under the weather.
The Fugue, trained by John Gosden, cruised into contention with a couple of furlongs remaining and brushed off the Aidan O'Brien-trianed market rival Venus De Milo with contempt as she swept four lengths clear.
Scintillula set a furious pace under Kevin Manning and established a lead of at least five lengths over Venus De Milo, who had the same advantage over the remainder.
Just as Venus De Milo had edged past halfway down the home straight, her jockey, Ryan Moore, will have spotted Buick cruising into contention himself and then quickly into the distance.
Owner-breeder Lady Madeleine Lloyd-Webber also provided the winner of this event through Dar Re Mi in 2008.
William Buick said afterwards: "I was so delighted for the filly that she did it that way.
"She showed everyone her full potential and everyone at home as they had so much confidence in her.
"It's really nice for her to do it like she did as she's shown everyone how good she is and how well she can travel.
"She saw the mile and a half out really well - she's awesome. She loves this ground."