Darley July Cup winner Mayson will miss the Betfred Sprint Cup at Haydock on Saturday because of a dirty scope.
Trainer Richard Fahey admitted it was a blow having to rule the four-year-old out of the six-furlong Group One.
"He just didn't scope right so we can't take a chance. It's disappointing for everyone, but I suppose that's how it goes sometimes," said the Musley Bank handler.
"Because we are not running him it shouldn't be too long. He should recover quick enough.
"There's the Abbaye (at Longchamp) and he's in at Ascot (Qipco British Champions Sprint) as well so we'll see."
Fahey now has to rely on outsider Majestic Myles in the Merseyside feature.
"He's in good form but it's a step up," he said.
Kingsgate Native and Reply were the only other withdrawals at the 48-hour final declaration stage, leading a field of 15 headed by the Australian mare Ortensia.
Paul Messara's flag-bearer came good in August, posting fine wins in the King George Stakes at Glorious Goodwood and York's Nunthorpe Stakes.
Last year's Sprint Cup runner-up Bated Breath was only sixth to Ortensia at York, but Roger Charlton's charge broke the five-furlong course record at Haydock when winning the Temple Stakes in May.
Charlton also saddles Genki, who was fourth 12 months ago and third in 2010.
Richard Hannon is hoping Strong Suit can prove effective back at six furlongs.
Robert Collet's Wizz Kid represents France, while the Tom Hogan-trained Gordon Lord Byron and Wokingham winner Dandy Boy from David Marnane's stable are the two Irish-trained challengers.
Society Rock, Hawkeyethenoo, Confessional, Elusivity, Hitchens, Soul, Es Que Love and Majestic Myles complete the line-up.