Epsom Derby hero Camelot features among 37 initial entries for the King George at Ascot on 21 July.
The 2000 Guineas winner completed the Classic double on Saturday and is being touted as a potential Triple Crown winner.
The Irish Derby would seem his most likely next port of call, but he could then step up and take on his elders, with the King George a possibility.
The colt is one of a host of entries for Ballydoyle maestro Aidan O'Brien, which includes Coronation Cup winner St Nicholas Abbey and Oaks heroine Was.
Dubai World Cup star Monterosso has been given the option by the Godolphin team, while last year's Arc scorer Danedream is a potential raider for German trainer Peter Schiergen.
Nathaniel won the Group One last year and could defend his crown for John Gosden, whose Grand Prix de Chantilly winner Aiken and 2011 Leger hero Masked Marvel could also feature.
Other interesting candidates include the Michael Stoute-trained Sea Moon, 2011 Oaks winner Dancing Rain, Jim Bolger's pair of Light Heavy and Parish Hall and potential Japanese raider Deep Brillante.
French trainer Corine Barande-Barbe has confirmed her stable star Cirrus Des Aigles as a likely participant in the Betfair-sponsored event.
The six-year-old is a course winner having landed last year's Champion Stakes and he has enjoyed a fine start to 2012, landing the Dubai Sheema Classic and the Prix Ganay.
"We plan to run Cirrus Des Aigles in the King George and he will either run in the Prince of Wales's Stakes or the Grand Prix de Saint-Cloud beforehand," said Barande-Barbe.
"I want to see what is entered in both races before making a decision, but there will be good horses in both races.
"He has been in very good form since the Prix d'Ispahan. I wasn't disappointed he got beaten at Longchamp (over nine furlongs) because we had to make the running.
"In hindsight, we probably should have gone a faster pace because Golden Lilac was having her first start of the year and we know Cirrus Des Aigles has more stamina than her.
"It's hard because there is no pace in French racing and the horse had run over 12 furlongs in Dubai and then 10 and a half in the Prix Ganay after that, so how the race panned out was not in his favour.
"The key to him is a fast pace, which makes him perform better, but he doesn't get that in France. He turned six on 8 May, but he still appears to be improving and growing, so hopefully he will race for another couple of years.
"He is also in the Irish Champion Stakes and Qipco Champion Stakes, so he can attempt the double."