The Wow Signal will miss the Keeneland Phoenix Stakes at the Curragh on Sunday.
John Quinn's unbeaten Coventry Stakes scorer was set to chart a route from North Yorkshire to Ireland but scoped dirty after a workout on Tuesday morning.
Qunn said: "He can't run at the weekend, which is obviously disappointing, but it's not the end of the world.
"He scoped dirty this morning, so we'll have to backtrack a bit.
"We were very pleased with him in his work this morning, but these things can clean up quite quickly so we should get him back soon enough.
"We'll have a look at the Morny (Deauville), but there's also races like the Middle Park and the Dewhurst (both at Newmarket) to think about."
The Wow Signal, who was purchased by Al Shaqab Racing following a runaway Ayr success on debut, had been the second-favourite in the betting behind exceptional Queen Mary winner Anthem Alexander.
Kool Kompany has been supplemented for the Group One over six furlongs in what still looks a white-hot renewal of the coveted sprint.
Richard Hannon's talented youngster was added to the field at a cost of €20,000 after claiming big-race honours in the Prix Robert Papin at Maisons-Laffitte last month.
He had previously won the Railway Stakes at the Curragh on 28 June.
As many as 12 other rivals, and Kool Kompany's stablemate, Tiggy Wiggy, could stand in his way.
English interests could be further spiked by the presence of Ahlan Emarati and Mind Of Madness, trained respectively by Peter Chapple-Hyam and David Brown.
Aidan O'Brien must choose from Dick Whittington, Rule The Waves, The Great War, War Envoy, I Am Beautiful and Simply A Star.
The unbeaten Beach Belle, trained by Kevin Prendergast, is still in the hunt, as is Cappella Sansevero from Ger Lyons' yard and Johnny Murtagh's Kasbah.
Anthem Alexander is the 11-8 market leader with Paddy Power.