Connections of Danedream have spoken of their "great sadness" at having to withdraw the Prix de l'Arc de Triomphe winner from her bid for repeat glory at Longchamp on Sunday.
Danedream is unable to travel to France as her stables at Cologne racecourse were on Monday placed into quarantine due to a serious outbreak of an equine infection.
A statement issued by trainer Peter Schiergen and part-owner Heiko Volz on Wednesday afternoon read: "It is with deep regret and great sadness that we were forced to take Danedream out of the Prix de l'Arc de Triomphe on Tuesday morning.
"We learnt on Monday afternoon that the Cologne racecourse, where Danedream is stabled at Peter Schiergen's yard and where she had only just completed her final preparation in view of another start in the Arc, was quarantined with immediate effect.
"We immediately contacted the relevant authorities and veterinaries to see if there was anything that could be done to allow her to take her chance in Paris on Sunday, but unfortunately we, as everyone else concerned at Cologne racecourse, have to abide by the rules and accept that she will not be travelling to Longchamp.
"We, as well as everyone who has worked with or looked after Danedream, are absolutely devastated. Winning the Arc last year was a 'once in a lifetime' experience and simply unforgettable.
"Coming from a country where the sport is already facing so many difficulties, but where Danedream had succeeded in giving it a wonderful injection of enthusiasm, we are incredibly saddened that there is no fairytale ending.
"Questions will have to be asked in the future how this situation could arise in the first place at a track that is Germany's major training centre. So many people are concerned, so many dreams shattered.
"However, we have received tremendous support from so many people and we would like to thank everyone for all the heartfelt messages that were sent.
"Danedream will always be special and she will always be an Arc winner. For that, we will always be grateful."