Trainer Ger Lyons accepts Lily's Angel is "the one to beat" when she chases further Listed gains at Dundalk on Friday night.
The four-year-old filly is unbeaten on an artificial surface, and arrives at the Louth circuit on the back of a brilliant second in the Matron Stakes at Leopardstown in September.
Lily's Angel now attempts to win the one-mile Irish Stallion Farms EBF Cooley Fillies Stakes for a second successive season.
Lyons said: "We're sticking to the same routine as last year.
"She'll get a break after this before we rev her up for Dubai. We always said the Cooley Stakes would be her final run.
"She has it all to do under a penalty but, realistically on figures, she's the one to beat. The horses don't know that, but she's never let me down."
Lyons also saddles Harmonic Note and Angela's Dream.
The Meath handler said: "Harmonic Note's always worked like a very good horse but didn't really put it together on turf, even though she was Listed-placed at Goodwood.
"She's in really good form and she likes Dundalk. She heads to the mares' sales in December after this.
"Angela's Dream looks up against it and would need to run a career-best by a long way to finish third.
"Unfortunately she looks well out of it on figures and also has a bad draw. She's an honest sort and it's her last run before she goes to the sales so we've nothing to lose."
Trainer Eddie Lynam believes Pearl Of Africa, who drops to Listed class after two tries in Group company, has it all to do to peg back the likely favourite.
He said: "Lily's Angel sets the bar. If you beat her you win as she's the best filly in the race and looks capable of carrying the penalty.
"Our horse is an improver. It looks a much tougher renewal this year. Last year horses in the 80s where second and third but it's a stronger race this time.
"She seems in good form although you never quite know with fillies at this time of year. Johnny Murtagh is booked and we're hoping for the best as she's a course and distance winner."
Former German-trained Viletta has just her second start for Michael Halford.
Halford said: "She got stuck in the ground at Leopardstown the other day. She came out of the race well and this is her last opportunity so we'll take our chance."