Declaration of War has been drawn in stall five as he attempts to give Aidan O'Brien a first victory in the Breeders' Cup Classic.
The American-bred colt won the Queen Anne Stakes at Royal Ascot and the Juddmonte International at York during the summer and will run on dirt for the first time at the weekend.
He will be jockey Joseph O'Brien's only ride at the meeting.
The other European runner in the Classic is Marco Botti's Planteur who will break from stall three.
Last year's one-two Fort Larned (seven) and Game On Dude (nine) are back again with Mucho Macho Man leaving gate six.