Matt Ryan helped the Atlanta Falcons to a 24-17 victory over Washington Redskins, guaranteeing the Falcons a first-ever 5-0 start in their franchise history.
Michael Turner ran 13 yards for the go-ahead score with less than three minutes remaining, with Ryan completing 34 of his 52 passes to earn Atlanta the win.
It was an eighth consecutive home loss for the Redskins, with Heisman Trophy winner Robert Griffin III having to leave the field with concussion.
Shaun Suisham kicked a last-gasp 34-yard field goal to guide the Pittsburgh Steelers to a 16-14 triumph over the Philadelphia Eagles.
The Eagles took the lead on a two-yard touchdown pass from Michael Vick to Brent Celek with less than seven minutes remaining, but the Steelers responded by driving 64 yards to set up the winning kick, including a pair of key third-down conversions by quarterback Ben Roethlisberger.
Andrew Luck and Reggie Wayne teamed up to wipe out an 18-point half-time deficit and give Indianapolis Colts a stunning 30-27 win over Green Bay Packers.
And the Miami Dolphins avoided last-minute heartbreak as Reshad Jones picked off Andy Dalton's overthrown pass to preserve a 17-13 victory over the Cincinnati Bengals, ending two weeks of miserable finishes.
Elsewhere, Justin Tucker (pictured below) made all three of his field goal attempts as the Baltimore Ravens kept the Kansas City Chiefs out of their end zone to preserve a 9-6 victory.
Victor Cruz made a career-best three touchdown catches and Ahmad Bradshaw showed good footwork as the New York Giants rallied to beat the Cleveland Browns 41-27.
An NFL record fell in New Orleans as Drew Brees became the first man to throw a touchdown pass in 48 consecutive games.
The Saints quarterback had previously shared the all-time mark with the late Johnny Unitas but took sole ownership in the first quarter during his team's 31-24 win against the San Diego Chargers when his 40-yard pass found Devery Henderson.
He later threw three shorter-range touchdown passes to Marques Colston.
Tom Brady (pictured below) and the New England Patriots got the better of Peyton Manning and the Denver Broncos in Foxborough, coming out on top by a 31-21 margin.
Brady won the latest clash of the superstar quarterbacks, launching one touchdown pass to find Wes Welker and running in a TD himself. Manning had three touchdown passes but was also responsible for a fumble that led to Stevan Ridley grabbing a deserved TD.
Shane Vereen also touched down for Denver who led 31-7 at one stage before the Broncos rallied with late scores from Eric Decker and Brandon Stokley.
The San Francisco 49ers embarrassed the Buffalo Bills, with QB Alex Smith's throwing 303 yards to earn three touchdowns in a 45-3 success, while the Jacksonville Jaguars were humiliated in front of an unhappy home crowd, losing 41-3 to the Chicago Bears. For the second time inside a week, Charles Tillman and Lance Briggs returned interceptions for touchdowns as the Jaguars were routed.
A pair of touchdowns from Percy Harvin brought the Minnesota Vikings a 30-7 home victory over the Tennessee Titans, while the Seattle Seahawks battled out a 16-12 win on the road against the Carolina Panthers.