Ben Crane carded a five-under-par 65 on Friday to open up a six-shot lead in the FedEx St Jude Classic before the weather brought a premature end to play in Memphis.
Crane stormed out in front with a flawless first 17 holes which included six birdies. He bogeyed the par-four 18th, but still finished the day well ahead of the pack.
Sweden's Carl Pettersen and American Jason Bohn were tied for second on six under. Both were three under for the day - Pettersen had one hole left, and Bohn two - when heavy rain that had twice delayed the action finally forced organisers to suspend play.
Davis Love III (70) and Billy Horschel (68) were in at five under and shared fourth spot with their fellow American Peter Malnati, who registered a 65 on Thursday and was one of the frustrated onlookers on Friday.
Goosen was one of a cluster of players a stroke back on four under following his opening 66, with Mickelson a further shot adrift after his first-round 67.
Mickelson was joined on the three-under mark by Graeme McDowell and Ian Poulter. The Northern Irishman signed for a 68 on Friday, while the Englishman was two under for his second round with one hole to play.
Padraig Harrington was level for the round and two under overall after two holes when play was suspended. Darren Clarke did not start his round.
Play will resume at 7am local time on Saturday (1pm Irish time), when better weather is forecast.