Americans Matt Kuchar, Scott Langley and William McGirt were tied for the lead after the first round of the RBC Heritage at Harbour Town.
Kuchar shrugged off his Masters near-miss last week and shot a five-under-par 66 on a cool, breezy morning at Harbour Town on Hilton Head Island.
"Once I got out there this morning, I was ready to go," the six-times PGA Tour winner told Golf Channel after finishing in style with a 15-foot birdie at his final hole.
"I didn't miss many shots. I found the fairways a lot, not only the fairways but the right (correct) side of the fairways to have a good approach.
"I had very good control off the tee and found a lot of greens [with my irons]. This morning was tricky, so to shoot five birdies, no bogey, was really good."
Kuchar was joined on five under by Langley, who would have led on his own but for a bogey on the 18th, and McGirt.
Graeme McDowell opened his defence of the title with a level-par 71. Late dropped shots on the 16th and 18th hurt McDowell.