The O'Byrne Cup will have a new home this year after Dublin's young guns were beaten 0-09 to 0-06 by a determined Wicklow side at Parnell Park.
With their senior players and management away at a training camp in La Manga, the competition's defending champions again fielded a team mainly composed of Under-21 players.
But the Dubs could only muster two points in a first period that failed to ignite. John Sheanon and John O'Brien were the home side's only scorers as they trailed by 0-05 to 0-02 at the break.
Although they lost the services of Dean Odlum after an early yellow card, Wicklow were able to carve out opening half points for Tony Hannon (0-02), Paul Earls, Jonathan Kinch and Darren Hayden.
Leighton Glynn was an influential presence at both ends of the pitch for Mick O'Dwyer's side, but there might have been a different outcome had Dublin substitute Bernard Brogan found the net.
Brogan blazed wide when presented with a goal-scoring chance after a mistake by Wicklow goalkeeper Mervyn Travers.
And the same player hit the butt of the post in the 58th minute as the Dubs looked to get back on terms.
As it was, further points from Hannon, who was shown a yellow card late on, and Kinch steered Wicklow home.
Playing at full-forward, Dean Rock, son of Dublin legend Barney Rock, put his name to three second half points.
Rock was one of the best players on the day for the Metropolitans, who also had James O'Connor yellow-carded.
Elsewhere, Meath coughed up a half-time lead at Newbridge as Kieran McGeeney's Kildare side battled their way to a 1-10 to 1-08 O'Byrne Cup quarter-final win.
The Lilywhites fought back to level the game at 1-08 apiece before late points from Mark O'Sullivan and Ken Donnelly sealed the win.
Three points from Cian Ward, allied to a well-taken goal from Joe Sheridan, had Meath leading by 1-06 to 0-05 at half-time, while Kildare came to terms with midfielder Daryl Flynn's yellow card.
Ward then extended Meath's lead to five points before this already exciting encounter ignited with a a 42nd minute goal from Kildare full-forward Willie Heffernan.
Eoin Reilly kept Meath on course with a point but that proved to be the visitors' final score.
Michael Conway, arguably Kildare's most effective player, burst forward from left half-back to score his second point and then efforts from Heffernan and O'Sullivan brought the sides level.
The tide was turning and Meath, who lost David Bray to a yellow card, could not respond as Kildare teed up a semi-final meeting with DCU next Sunday.
DCU 0-11 DIT 0-05
Mayo's Conor Mortimer scored six points as DCU braved heavy rain and gale force winds in Glasnevin to beat DIT 0-11 to 0-05 and secure an O'Byrne Cup semi-final spot.
DIT made the better start to this capital clash thanks to the industrious work of Dublin star Mark Vaughan (0-02), and led by 0-04 to 0-03 at half-time.
However, Vaughan's side could only manage one more point on the restart, from Cavan's Martin O'Reilly, as a rampant DCU attack proved to be sharper in front of the posts.
Louth 4-12 Longford 0-05
An energetic Louth side comfortably accounted for a sluggish Longford at Pearse Park.
Eamon McEnaney's charges were certainly fired up for this encounter and led by 2-01 to 0-0 after just five minutes, with Adrian Reid and Shane Lennon the goalscorers.
Longford edged back on the restart, cutting the gap to eight points, however they failed to score in the closing 30 minutes as goals from Darren Clarke and Lennon confirmed Louth's semi-final qualification.
O'BYRNE CUP RESULTS:
Louth 4-12 Longford 0-05
Wicklow 0-09 Dublin 0-06
Kildare 1-10 Meath 1-08
DCU 0-11 DIT 0-05
O'BYRNE SHIELD ROUND-UP:
A clinical second half display earned Laois a convincing 4-18 to 1-04 win over neighbours Kilkenny in the O'Byrne Shield at McCann Park in Portarlington.
Goals came from all angles in the opening half as the O'Moore men established a 4-04 to 1-04 half-time advantage.
A brace of Zach Tuohy goals, and one each from Donie Brennan and Chris Bergin saw Laois take control.
Defences tightened up on the restart, but Laois staged an exhibition of point-scoring in the second half to ease into the next round.
Goals in either half from Eric McCormack and Mark Carpenter steered Carlow past Offaly at O'Connor Park, with the visitors running out 2-11 to 0-13 winners.
Despite Luke Dempsey's charges being the more balanced side, this O'Byrne Shield tussle was on a knife-edge throughout and was largely an entertaining contest.
Carlow edged Offaly by 1-06 to 0-07 at the end of an absorbing first half.
Ken Casey (0-04) top-scored for Offaly and kept them in touch on the restart but Carpenter's goal really sealled the issue.
Meanwhile, Mayo man Mark Ronaldson and Barra O'Rorke (0-03 each) were UCD's top-scorers as they beat hosts Athlone IT by 0-12 to 0-08.
UCD were more clinical in front of the posts but were only 0-06 to 0-05 ahead at half-time.
Trevor Phelan and Ger Dennigan kept Athlone IT very much in contention, before UCD's shooting accuracy came to the fore.
Westmeath ground out an impressive extra-time victory over hosts Wexford in the O'Byrne Shield at Monamolin.
In a thrilling game, the visitors certainly fought hard during 90 minutes-plus of football.
The sides were level at 1-09 a piece at the end of normal time thanks to Thomas McDaniel netting for Westmeath and Patrick Naughter registered Wexford's first goal.
Extra-time saw the sides evenly matched again with Francis Spollen netting for the visitors, and although Jason Murphy grabbed Wexford's second goal, Westmeath took the spoils.
O'BYRNE SHIELD RESULTS:
UCD 0-12 Athlone 0-08
Carlow 2-11 Offaly 0-13
Westmeath 2-13 Wexford 2-11 AET
Laois 4-18 Kilkenny 1-04