UK airline Flybe is to operate services from London City Airport from this autumn.
The carrier will begin flights from the Docklands Airport on October 27 and expects to carry around 500,000 passengers a year.
From London City, Flybe will offer four daily services to Dublin and Edinburgh, three flights a day to Belfast and Exeter, and twice-daily services to Inverness.
This is the first time that Flybe has flown from London, with the new services augmenting its flights from other UK airports.
Flybe also intends to operate to European ski resorts and to French and northern Spanish destinations, with more details of these services expected soon.
"Today's announcement is a significant landmark in the re-birth of Flybe. We are delighted to re-enter the London market at London's most convenient airport following a rigorous profitability analysis utilising our strict route assessment model," Flybe's chief executive Saad Hammad said.
"Dedicating five growth aircraft initially to these new routes is a major statement of intent and we look forward to building a successful and growing presence there over the coming years," he added.
London City Airport chief executive Declan Collier said the airport is poised for significant growth in the next 10 years - growth that will see it achieve 120,000 flight movements per annum, with an associated six million passengers by 2023.