167 jobs are to be generated in Cork and Dublin at six companies.
The new jobs are to be spread across a range of sectors including Information and Communications Technology, medical technology, financial services and digital media.
The investments are supported by the Department of Jobs, Enterprise and Innovation, through IDA Ireland.
Minister Richard Bruton said the investments would benefit other areas of the economy.
The companies making the announcements are:
- 10Gen, which is to create 60 jobs in Dublin with the establishment of its European headquarters.
- Loop1 Systems is to create 17 new jobs in Cork with the establishment of a sales, customer support and technical centre providing training and professional services to multinational companies.
- Whitehouse Analytical Labs, an analytical testing facility, has chosen Ireland for its first round of international expansion, which is to create 35 new jobs in Cork.
- IMSTech Gmbh, a provider of manufacturing solutions for the life sciences sector, is to establish a research and manufacturing competency centre in Cork with the creation of 35 highly-skilled jobs.
- PE Lynch, a producer of algorithmic trading software for banks and brokers, is to establish its European headquarters in Dublin.
Meanwhile, Etsy Inc, the leading online marketplace for handmade and vintage items, is also to establish a new European, Middle East and Africa headquarters in Dublin.
''Ireland's reputation as a location for fast-growing business continues to go from strength to strength. These six companies announcing investments and job creation in Ireland today have come here in order to take advantage of our wealth of talent, track record as a location for FDI, technology capabilities and attractive rate of corporate tax,'' commented IDA Ireland's chief executive Barry O'Leary.