The US multinational, Merit Medical, is to create 200 jobs in Galway and a further 37 jobs are to be created in software firm Copperfasten Technologies.
The Taoiseach officially launched the Merit Medical expansion, opening a €20m IDA supported facility.
The medical devices company, Merit Medical, is in Galway since 1996 and currently employs 379 people.
Copperfasten Technologies was supported by Enterprise Ireland.
The extra 200 jobs in Merit Medical will bring the workforce to well over 500.
The jobs will be in research and development, operations support and manufacturing. Over one third are graduate positions.
Merit is a leading manufacturer of medical devices used mainly in the areas of cardiology, radiology and endoscopy.
The new €20m facility at Parkmore will be a designated centre of excellence for some of Merit's new products and technologies.
IDA Chief, Barry O'Leary, said Merit was a key player in the cluster of medical device companies operating successfully from the West of Ireland.
A further 37 new jobs are to be created at the Galway software firm Copperfasten Technologies.
The company is based in Salthill and currently employs 15 people.
The expansion is based on a €500,000 investment by Enterprise Ireland. The company produces Internet security solutions