The Irish Motor Neurone Disease Association (IMNDA) has received a total of €1.4m in donations from the "Ice Bucket Challenge".
An estimated half a million Irish people have taken part in the online trend.
The Irish Motor Neurone Disease Association helps some 330 motor neurone disease (MND) patients and their families each year.
Chairman of IMNDA, Dr Declan Mac Daid, said the organisation was "blown away" by the generosity of the Irish public.
"We look forward to investing in services and technology into the future..."
25% of the donations will go towards clinical research into causes and treatments for motor neurone disease which claims the lives of over 100 people in Ireland each year.
It is not yet known how the rest of the donations will be spent.
A questionnaire is being prepared and will be sent to every patient and user of the IMNDA service across Ireland to determine how the money should be spent.
"The number of patients has risen from 220 in 2009 to 330 today. Through the generosity of the Irish public, we are now in a better position to help those people who have yet to be diagnosed."
Patients, staff and supporters at IMNDA today posted a "thank-you" video on-line, in acknowledgement of the effort made by donors.