A new nursing home in Bray, Co Wicklow is promising 120 new jobs over the next three months in nursing, administration and other roles.
Elsewhere, professional services company EY is creating 80 jobs on the island of Ireland, and travel firm TripAdvisor is to create 50 jobs in Dublin.
McMahon Healthcare Group, the developer of Cairnhill Nursing Home, which opens today, said its new positions will include catering, managerial and support roles.
The group has operated a 42-bed nursing home in Foxrock, Co Dublin, for the past 17 years.
EY has said it is to create 80 jobs across its five sites on the island of Ireland.
The company, known as Ernst and Young until it rebranded last July, already employs 1,260 people in Ireland.
It hopes to fill 40 of the new positions by Christmas and the remainder early next year.
EY provides assurance, advisory tax and transaction services to its clients.
Meanwhile, a further 50 jobs are to be created in Dublin with the establishment of a new engineering hub for TripAdvisor, the world's largest travel website.
All the jobs will be web engineering roles and recruitment is to begin immediately.
The new Dublin hub will be located in the area known as Silicon Dock in the Dublin Docklands.