Taoiseach Enda Kenny is to take part in a live webcast with a number of businesses involved in online retail.
In a statement, Mr Kenny said €3.7bn was spent online last year, with 70% going to retailers outside the country.
This presented a real opportunity for Irish traders, he said.
Speaking in advance of the event, Mr Kenny said: "I want to hear directly from retailers their experiences and needs.
"In broadcasting online, I want to start as broad a conversation as possible about the progress we can make in this area and help create more jobs."
Topics for discussion are expected to include the potential that online trade offers, and the challenges and opportunities associated with selling online.
The webcast will be broadcast on RTÉ.ie and the Government's website Merrionstreet.ie at 12pm on Friday 6 September.