The Taoiseach and 18 ministers will travel to 21 countries over the coming week as part of a "Promote Ireland" programme around St Patrick's Day..
Enda Kenny will meet US President Barack Obama in the White House.
Tánaiste and Minister for Foreign Affairs Eamon Gilmore will also travel to the US where he will meet US Secretary of State John Kerry.
Mr Gilmore said the costs of the visits will be kept as low as possible.
He said the Patrick's Day events are a very cost effective way of promoting Ireland around the world.
Six ministers in total will travel to the US over the St Patrick’s festivities.
Meanwhile, Minister for Enterprise, Jobs and Innovation Richard Bruton will visit Germany, while Minister for Education Ruairi Quinn will go to China.
Minister for Transport, Tourism and Sport Leo Varadkar will visit Japan and Korea.
Minister for Public Expenditure and Reform Brendan Howlin will visit Singapore, Indonesia and the Philippines.
Minister of State Jan O'Sullivan will go to Saudi Arabia, while Minister for Justice Alan Shatter is visiting the Middle East.
Minister for Health James Reilly will visit Birmingham and London.