The sister of Irish woman Catherine Gowing, who went missing six days ago in Wales, has appealed to the local community to help find her sister.
Emma Gowing was speaking at a news conference in north Wales, after police were granted a 36-hour extension to question a man arrested on suspicion of Ms Gowing's murder.
She said her "beautiful sister" was the light of her life and her family was deeply shocked by the disappearance.
She urged people living in the area to help, saying: "Look out of your windows, look as you drive or head to work.
"Check your local street, car parks, garages, wasteland or anywhere the car may be left. Please look, please search and please help us find my beautiful sister."
Police now say the last known sighting of the 37-year-old was at an Asda supermarket in Queensferry last Friday evening.
They say Ms Gowing entered the supermarket shortly after 8pm and left at 8.40pm.
Detectives said she was alone at the time.
Police said she was wearing blue jeans, a light brown khaki fleece zipped top, and plain black flat shoes. Her hair was tied up.
She was carrying a plastic Asda bag and a pizza-type box.
Officers said a forensic examination continued at her home today.
Detectives confirmed that co-ordinated searches are taking place at various locations in an attempt to find Ms Gowing, her car - a plum/burgundy coloured Renault Clio (00D99970) - and personal items that are missing from her home.
They also confirmed that they are examining CCTV in the area.
Ms Gowing, who is originally from Co Offaly, has been living near Mold, Flintshire, for the past few years.
Speaking on RTÉ's News At One, her employer said workmates were devastated over her disappearance.
David Evans said staff at the veterinary practice became concerned for Ms Gowing when she failed to turn up for work on Monday morning.
He said: "Well, we thought since her car was missing, we thought maybe she had gone somewhere for the weekend and got into some difficulty or something like that.
"We informed the police as soon as she didn't turn up for work at nine o'clock on Monday morning and we left it with the police then."
Mr Evans also said that one of the nurses at the practice was worried when she received "half a text message" from Ms Gowing's phone over the weekend.
He said: "She was a very caring, dear person really, very easy to get on with. She was such a pleasant girl."
The 46-year-old man who appeared at Prestatyn Magistrates' Court this morning was known to Ms Gowing.