Pentagon chief Leon Panetta has said that the US would continue to attack al-Qaeda in Pakistan despite complaints from Islamabad that the drone strikes violate its sovereignty.
"We have made it very clear that we are going to continue to defend ourselves," Secretary of Defence Mr Panetta said a day after the US announced the killing of al-Qaeda's number two Abu Yahya al-Libi.
"This is about our sovereignty as well," Mr Panetta added, arguing that al-Qaeda militants who orchestrated the 11 September attacks on the US were in Pakistan's tribal areas.
"The leadership of those who were involved in planning this attack are located in Pakistan, in the FATA (Federally Administered Tribal Areas)," he said.
Mr Panetta confirmed the strike on "another deputy leader" of the terror group, referring to al-Libi who once escaped from a US jail in Afghanistan and had escaped previous assassination attempts.
A trusted lieutenant of Osama bin Laden, al-Libi appeared in countless al-Qaeda videos and was considered the chief architect of its global propaganda machine.
Pakistan has lodged a protest with Washington over a string of recent drone attacks on its northwestern tribal areas which it has branded as "unlawful, against international law and a violation of Pakistan's sovereignty".
Pakistani-US relations went into free fall last year when a CIA contractor shot dead two Pakistanis, a US raid killed al-Qaeda chief Osama bin Laden, and US air strikes in November killed 24 Pakistani soldiers.
Mr Panetta acknowledged that India and the US had "often deep" differences with Pakistan but said New Delhi and Washington needed to work to overcome them.
"Pakistan is a complicated relationship for both of our countries but one that we must work to improve," he said in a speech in New Delhi where he met the country's leaders to discuss China and Afghanistan.