Noel Ahern,TD, and Ned O Keeffe,TD, have said that they will not be contesting the next election.
Noel Ahern made the announcement at his party's convention in Dublin North West.
Noel is a brother of the former Taoiseach and leader of Fianna Fáil, Bertie Ahern.
Noel Ahern was first elected in 1992.
He was re-elected to the Dáil in May 2007 and became Minister of State at the Department of Transport (with special responsibility for Road Safety) from May 2008 - April 2009.
Between June 2007 and May 2008 he was Minister of State at the Department of Finance with special responsibility for Office of Public Works and was a member of the Cabinet Committee on Social Inclusion.
He was also a member of Dublin City Council 1985-2002.
Meanwhile, Fianna Fáil's Ned O'Keeffe has announced that he will not contest the next election.
Speaking at a convention in Midleton, Co Cork, he said he will not run again in Cork East and has said his son, Kevin, will now contest his seat.
Mr O'Keeffe served the Cork East Constituency for almost three decades and said he had taken the decision to stand down on age grounds.
He said he is 68-years-old now and would be 73 at the next election if the Dáil ran its full term.
Ned O'Keeffe launched a stinging attack on Fianna Fáil saying the party had lost touch with ordinary people and he described the establishment of NAMA and the arrival here of the IMF as disastrous.
Fianna Fáil will now be represented in the Cork East Constituency in the general election by sitting TD Michael Ahern and by Ned O'Keeffe's son Kevin O'Keeffe.