In Co Wexford, a medical device firm is to create 70 jobs in Enniscorthy.
ClearStream Technologies says it will create the jobs over the next three years in product engineering, research and development, manufacturing, and sales and marketing.
The jobs are part of an expansion plan supported by Enterprise Ireland.
ClearStream Technologies currently employs 230 workers, and designs and manufactures medical devices such as catheters and stents.
Enterprise Ireland's investment will support a dedicated research and development centre, new product development, production facilities and management development training.
Elsewhere, 30 new software jobs have been promised for Dublin.
The new jobs in Murex, a French financial software firm, will be in software development, business development and consulting. The company already employs 60 workers in Shelbourne Road in south Dublin.
The firm, which established the software centre 11 years ago, expects to fill the new positions within three years.
The new workers will have a combination of degree and masters qualifications in maths, engineering and computer science.
