A plane carrying eight people crashed in a residential area of Karachi setting buildings on fire and further casualties are feared.
The Civil Aviation Authority said the plane had gone down after taking off from Karachi airport.
Spokesman Pervez George said it was a Russian-built cargo plane that was bound for Sudan.
The crash triggered a massive blaze in the Dalmai neighbourhood, where the Pakistan Air Force and Navy have residential apartments close to the airport, witnesses and officials said.
Television broadcasts showed rescue workers fighting a huge blaze at the scene.
On 5 November a small plane chartered to an international oil company crashed after take-off from Karachi airport, killing all 21 on board.
