600 people will be employed at the facility.
In 2005, Coca-Cola announced its decision to consolidate production from its plants in Drogheda, Co Louth, Naas Road, Dublin, and Lambeg, Antrim, to a new site at Knockmore Hill, Lisburn.
256 jobs were lost with the closure of the Drogheda site in 2007.
The new facility will serve the entire Irish market - north and south of the border.
The company said that following an extensive review of potential sites across Ireland, the 45-acre site at Knockmore Hill was chosen because of its water supply, road access and proximity to its former plant in Lambeg.
Coca-Cola continues to employ more than 450 people in the Republic.
