A spokesman for the company said that staff will be offered voluntary redundancies as well as opportunities to work elsewhere in the company.
IBM announced last year that it was moving its high-end server manufacturing operations for Europe, Africa and Asia to Singapore from Dublin.
The Dublin plant will continue to provide what the company called low-end and mid-range power-based systems for Europe, the Middle East and Africa.
The spokesman added that IBM is hiring people to work in its software and sales sectors here.
This follows last month's news that it was opening a new research centre in Mulhuddart in Dublin which will create over 200 jobs.
A spokesman for the company said that staff had been aware that the manufacture of the server had been moving to Singapore since last year.
Earlier this week, the US computer giant lifted its forecast for this year after reporting better than expected results for the first quarter of this year, helped by a pick-up in technology spending.
IBM said its net profit grew 13% from a year earlier to $2.6 billion, with revenue rising by 5% to a better than expected $22.9 billion.
Fine Gael's Enterprise, Trade & Employment Spokesman Leo Varadkar said the news would come as big blow to the Dublin 15 region.
'This is a huge disappointment for IBM's employees and for the whole of Blanchardstown,' he said.
'The company still has a major investment in west Dublin and I trust that its long-term commitment to the area is solid,' he added.
