The Taoiseach has urged every citizen to vote in Friday's referendum and to vote Yes to the Lisbon Treaty.
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At the final Fianna Fáil news conference of the campaign, Taoiseach Brian Cowen said he understood that many people are worried and are feeling the impact of the economic crisis, but he said the future was in their hands.
He said by voting Yes people would be helping Ireland achieve economic recovery by sending a powerful signal to job creators and investors that Ireland is and will remain at the heart of Europe.
The Taoiseach said the guarantees on issues of concern to Irish voters were comprehensive and watertight and had changed the dynamic of the campaign.
He said the guarantees have made people who voted No last time more comfortable about switching their vote.
Mr Cowen said that in the event of a No vote there would not be a Lisbon Three, but it would lead to a period of uncertainty with the possibility of a two-speed Europe developing.
Asked whether threatened industrial relations problems could impact on the Yes vote, Mr Cowen said these were issues that would be returned to, but Friday is about the Irish people deciding on their relationship with Europe.
He said the referendum was not about him or his Government or Fianna Fáil.
Speaking later on RTÉ's Six-One News, Mr Cowen said there will not be a change of Government if there is a No vote on Friday.
He said the Government's focus is on getting the treaty passed.