Kate and Gerry McCann have given their first television interview since police in Portugal officially named them as suspects in the disappearance of their daughter, Madeleine.
They told the Spanish TV channel, Antena 3, they were confident that they and their friends would eventually be cleared of any involvement.
The couple repeated their belief that the four-year-old is still alive, claiming they think she is possibly being held by someone in their house.
'I don't know how anyone could harm anyone as beautiful as Madeleine. I don't mean her appearance. I mean as a beautiful person', Mrs McCann said.
'I feel sad and I feel lonely and our life is not as happy without Madeleine,' she said. 'I feel anxious she is not with us.'
Mr McCann described the last time he saw his daughter at 9.05pm as he checked her as she lay sleeping before returning to the tapas bar to carry on with his evening meal.
'I was the last to see her. I saw her and thought how beautiful she was and thought how lucky I was to be a father of three children,' he said.
The couple said they were trying to ignore speculation in the media about who is responsible.
They also once again strongly denied reports that they sedated their three children.
Earlier this month they threatened legal action over 'hurtful' allegations they gave the youngsters sleeping pills on the night Madeleine vanished.
The McCanns reportedly chose Antena 3 for the interview ahead of more well-known broadcasters, such as Oprah Winfrey, because they believe their daughter is most likely to be in Spain, Portugal or north Africa.