The supermodel and Radio 1 host Nick Grimshaw launched the range at a special event at Topshop's flagship Oxford Circus store.
She said about the collection: "I just want everyone to find something they love to wear."
Duke Durmont featuring Jax Jones performed the hit Single I Got U at the launch, which was attended by Topshop boss Philip Green, his daughter Chloe Green, who also designs her own range of shoe's for the high street giant, actress Sienna Miller and the model's mother Linda Moss.
This Kate Moss for Topshop range is the first from Moss after a hiatus of four years, having designed her debut line in 2007.
She said of reprising her designing role at Topshop: "I have really missed being involved in the design process, and working with the team at Topshop.
"I am very excited to create a new collection that bears my name. Now more than ever, with London being at the forefront of fashion, as it feels like I'm back home working with Topshop."
The new Kate Moss for Topshop line is available to buy online and in stores from today.