Matt Groening's Futurama has been cancelled for a second time.
Entertainment Weekly has reported that the animated comedy will not be renewed by Comedy Central when it reaches the end of its seventh season.
Devised by Simpsons' creator Matt Groening, the sci-fi comedy originally aired in the US on Fox between 1999 and 2003.
Following a series of successful direct-to-DVD episodes, Comedy Central ordered two 26-episode seasons and brought the show back to television.
Comedy Central exec Dave Bernath claimed that the series has reached its "natural end" following "a helluva run".
He added that he was "thankful and feel a sense of gratitude toward the whole process - and that we found a way to keep going for 52 more episodes - than I really am even thinking about the ending. It's a blessing that it came back and lasted so long."
Creator Groening has refused to throw in the towel. He insists that he will search for a third TV home for Fry, Leela, Bender and co, saying: "We would love to continue. We have many more stories to tell."