David Arquette has reportedly said he believed estranged wife, Courteney Cox, was having an extra-marital affair with a 'Cougar Town' co-star.

In an interview on 'The Oprah Winfrey Show', the actor said that reports in the press linking Cox and Brian Van Holt made him certain that she was being unfaithful.

He said: "There were tabloid stories coming out about her and someone on her show having, you know, an affair.

"I thought she was having an affair with someone. Nobody would've said something like that if she weren't.

"I was angry with...the dynamic of our relationship. I was angry with my wife."

The 'Scream' star also admitted that he found it difficult to accept the break-up of his 11-year marriage, adding: "She came down really depressed one day, and was like 'I'm really just not happy'.

"I felt really sort of abandoned at that point. A deal is a deal."